Sodium Carboxymethyl Cellulose, also known as CMC and Sodium CMC, is odorless, tasteless and non-toxic powder, granule, or fibrous solid with white or yellowish color. It is a macro-molecule chemical substance that can absorb water and expand to form a transparent viscous liquid, which is neutral in terms of pH. Solid CMC is stable to light and room temperature and can be stored for a long time in dry environment. Last time, we talked about the safety of CMC used in food industry. Today, let’s discuss the safety of CMC used in pharmaceutical industry.
CMC has chemical inertia and physiological inertia. It does not participate in physiological metabolism. The main raw materials for CMC production are refined cotton, chloroacetic acid and NaOH. Although chloroacetic acid is highly toxic, the alkali in the reaction is excessive, so there is no residue. In addition, the high concentration of alcohol in the production process used as solvent and the high-temperature treatment will not cause microbial contamination.
Therefore, CMC can be used as an emulsifying stabilizer for injection, tablet adhesive and film-forming agents in the pharmaceutical industry. Carboxymethyl cellulose as membrane material can be used for skin grinding surgical wounds and traumatic wounds; Animal model studies show that the membrane could prevent wound infection, and there is no significant difference between the membrane and gauze dressing. Compared with gauze dressing, it is superior in controlling wound tissue fluid exudation and rapid wound healing and has the effect of reducing postoperative edema and wound irritation. Polyvinyl alcohol, CMC and polycarboxylic ethylene membrane prepared at the ratio of 3:6:1 is the best formula, which improves the adhesion and release rate of the membrane, prolongs the residence time of the preparation in the oral cavity, and significantly improves the efficacy of the preparation.
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SINOCMC TEAM